china hpmc pharmaceutical eye drops
Hypromellose can be dissolved in cold water to form a viscous solution, and its properties are close to the viscoelastic substances (mainly mucin) in tears. Therefore, it can be used as artificial tears.
The mechanism of action is to attach to the surface of the eyeball through the adsorption of the polymer, which mimics the effect of conjunctival mucin, thereby improving the state of ocular mucin reduction and increasing the eyeball retention time under the state of reduced tears. This adsorption does not depend on the viscosity of the solution, so it ensures that a very low-viscosity solution can also have a very long-lasting wetting effect. In addition, by significantly reducing the contact angle of the clean corneal surface and increasing the wetting effect of the cornea, it can also increase the stability of the pre-corneal tear film, which has been confirmed by the tear film rupture test study.